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Literature summary extracted from

  • Ganeshapillai, D.; Woo, L.W.L.; Thomas, M.P.; Purohit, A.; Potter, B.V.L.
    C-3- and C-4-substituted bicyclic coumarin sulfamates as potent steroid sulfatase inhibitors (2018), ACS omega, 3, 10748-10772 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.1.6.2 molecular docking of inhibitors 3-hexyl-4-methylcoumarin-7-O-sulfamate and 3-benzyl-4-methylcoumarin-7-O-sulfamate into the active site of steryl sulfatase Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 3-benzyl-4-methylcoumarin-7-O-sulfamate IC50 value 0.68 nM in intact MCF-7 cells Homo sapiens
3.1.6.2 3-hexyl-4-methylcoumarin-7-O-sulfamate IC50 value 0.68 nM in intact MCF-7 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.6.2 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 placenta
-
 Homo sapiens
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.6.2 0.008
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-hexyl-4-methylcoumarin-7-O-sulfamate
3.1.6.2 0.032
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-benzyl-4-methylcoumarin-7-O-sulfamate